To leave San Antonio, use US 281 south to get to Brownsville, I-10 east to get to Houston, I-10 west to get to El Paso, I-35 north to get to Austin, Waco, and Dallas/Fort Worth, I-37/US 181 south to get to Corpus Christi and Floresville, SH 16 north to get to Bandera, SH 16 south to get to Poteet, or US 281 north to get to Blanco and Johnson City. An alternate route to Austin is to use US 281 north and US 290 east. I-410 and SH 151 do not leave the city. However, Loop 1604 does go to small towns in the county.
San Antonio is a great place to start a day trip to New Braunfels, best known for its German culture and heritage, not to mention the Schlitterbahn (http://schlitterbahn.com/nb/), persistent in being voted the world's best waterpark; or to San Marcos, home of Texas State University and its Aquarena Center.
